IKZF3

Across TCGA patient cohorts, IKZF3 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IKZF3-associated genes across cancer lineages are ASNS, INPP4B, and PDCD4. Each is linked with IKZF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both IKZF3-to-partner and partner-to-IKZF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by IKZF3-low versus IKZF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKZF3→partner) and Y-score (partner→IKZF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.489	+2.321	.001	.034	3	3
UCEC	INPP4B →	-0.383	-3.700	.004	.001	3	2
UCEC	PDCD4 →	-0.709	-3.000	<.001	.001	3	2
SKCM	SF2 →	+0.177	+3.000	.009	.035	3	2
SKCM	ATM →	-0.453	-3.169	.021	.018	2	3
UCEC	EGFR_pY1068 →	-0.229	-3.321	.026	.010	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

ASNS by IKZF3 expression — UCEC

Explore this box plot interactively →