IKZF3

Across TCGA cell cohorts, IKZF3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,952 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible IKZF3-associated GO terms across cancer lineages are Post-transcriptional gene silencing, Regulation of fibrinolysis, and Xenobiotic metabolic process. Each is linked with IKZF3 in more than 7 cancer types. Because this analysis shows association rather than direction, both IKZF3-to-partner and partner-to-IKZF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Post-transcriptional gene silencing grouped by IKZF3-low versus IKZF3-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IKZF3→partner) and Y-score (partner→IKZF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Post-transcriptional gene silencing →	+0.063	+0.076	.004	.003	3	8
LIVER	Regulation of fibrinolysis →	-0.287	-0.073	<.001	.005	3	6
LUNG_SCLC	Xenobiotic metabolic process →	-0.072	-1.421	.001	<.001	3	6
SOFT_TISSUE	Sister chromatid cohesion →	+0.084	+0.059	.005	.008	3	6
BLOOD_Myeloma	Positive regulation of T cell differentiation →	+0.086	+1.466	.001	<.001	3	6
BLOOD_Lymphoma	miRNA processing →	+0.056	+1.331	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,952 associations by consensus.

Post-transcriptional gene silencing by IKZF3 expression — LIVER

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