IKZF3

Across TCGA cell cohorts, IKZF3 mutation is significantly associated with the RNA expression of many other genes, with 67 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IKZF3-associated genes across cancer lineages are FBXW10, FOXD3, and OR6J1. Each is linked with IKZF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IKZF3-to-partner and partner-to-IKZF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXW10 grouped by IKZF3-low versus IKZF3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKZF3→partner) and Y-score (partner→IKZF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FBXW10 →	+0.047	+3.762	<.001	.001	3	2
BLOOD_Leukemia	FOXD3 →	+0.348	+3.379	.004	.006	3	2
BLOOD_Leukemia	OR6J1 →	+0.029	+2.971	<.001	.003	3	2
LARGE_INTESTINE	CPLX4 →	+0.035	+4.029	<.001	.001	3	1
LARGE_INTESTINE	ACER1 →	+0.072	+3.145	.006	.004	3	1
LARGE_INTESTINE	NUPR2 →	+0.233	+3.103	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

FBXW10 by IKZF3 expression — BLOOD_Leukemia

Explore this box plot interactively →