IKBKG

Across TCGA patient cohorts, IKBKG mutation is significantly associated with the RNA expression of many other genes, with 238 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IKBKG-associated genes across cancer lineages are RNU6-478P, RPP25, and TRNAU1AP. Each is linked with IKBKG in more than 1 cancer types. Because this analysis shows association rather than direction, both IKBKG-to-partner and partner-to-IKBKG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-478P grouped by IKBKG-low versus IKBKG-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKBKG→partner) and Y-score (partner→IKBKG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-478P →	+0.333	+7.640	<.001	.009	3	1
UCEC	RPP25 →	+0.812	+3.354	.001	.005	3	1
UCEC	TRNAU1AP →	+0.337	+3.362	.009	.005	3	1
UCEC	PHLDA2 →	+1.470	+3.917	<.001	<.001	3	1
UCEC	LSM10 →	+0.425	+3.724	.001	<.001	3	1
UCEC	MRPS11 →	+0.523	+2.649	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 238 associations by consensus.

RNU6-478P by IKBKG expression — BLCA

Explore this box plot interactively →