IKBKG

Across TCGA pan-cancer cohorts, IKBKG RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated IKBKG data layer compared with 6 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher IKBKG RNA is associated with better overall survival. In most high-consensus cancer types, elevated IKBKG expression acts as an unfavorable survival marker, although some lineages such as SCLC and SKCM show a favorable association.

SCLC, SKCM, and COAD are the cancer types where IKBKG RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	II,III,IV	0.608	0.207	<.001	66	view →
SKCM	DFS	Tertile	II,III,IV	0.354	0.190	.001	52	view →
COAD	OS	Quartile	IV	0.191	0.763	.009	34	view →
LGG	OS	Median	All	0.853	0.935	<.001	32	view →
KIRC	DFS	Quartile	IV	0.190	0.472	.008	26	view →
PAAD	DFS	Tertile	II,III,IV	0.408	0.204	.002	23	view →
BRCA	DFS	Quartile	II,III,IV	0.839	0.916	.004	22	view →
UCEC	DFS	Quartile	All	0.766	0.869	.019	16	view →
LUSC	DFS	Quartile	III,IV	0.232	0.627	.003	15	view →
SARC	OS	Median	All	0.819	0.643	.003	14	view →
LAML	DFS	Quartile	All	0.278	0.555	.008	14	view →
LUAD	DFS	Median	IV	0.301	0.753	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

IKBKG–SCLC (OS)

Open the SCLC breakdown →