IKBKG

Across TCGA patient cohorts, IKBKG mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IKBKG-associated genes across cancer lineages are JNK2, Notch1, and p27_pT157. Each is linked with IKBKG in more than 1 cancer types. Because this analysis shows association rather than direction, both IKBKG-to-partner and partner-to-IKBKG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by IKBKG-low versus IKBKG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKBKG→partner) and Y-score (partner→IKBKG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.289	+3.700	.001	.001	3	1
UCEC	Notch1 →	+0.156	+2.584	.017	.011	3	1
UCEC	p27_pT157 →	-0.072	-2.584	.007	.011	3	1
UCEC	S6_pS240_S244 →	+0.602	+3.183	.001	.009	3	1
UCEC	Tuberin →	+0.455	+3.321	<.001	.009	3	1
UCEC	CDK1_pY15 →	+0.217	+1.896	.025	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

JNK2 by IKBKG expression — UCEC

Explore this box plot interactively →