IKBKG

Across TCGA cell cohorts, IKBKG RNA expression is significantly associated with the go_rna of many other GO terms, with 4,328 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible IKBKG-associated GO terms across cancer lineages are Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, Canonical NF-kappaB signal transduction, and Negative regulation of organelle assembly. Each is linked with IKBKG in more than 13 cancer types. Because this analysis shows association rather than direction, both IKBKG-to-partner and partner-to-IKBKG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway grouped by IKBKG-low versus IKBKG-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IKBKG→partner) and Y-score (partner→IKBKG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.128	+1.074	<.001	<.001	3	14
LIVER	Canonical NF-kappaB signal transduction →	+0.120	+1.328	.002	.006	3	13
BONE	Negative regulation of organelle assembly →	+0.080	+1.388	<.001	<.001	3	13
SOFT_TISSUE	Phosphatidylinositol biosynthetic process →	+0.045	+0.816	.001	.002	3	13
SKIN	Positive regulation of microtubule nucleation →	+0.135	+0.692	.002	.003	3	13
SKIN	Negative regulation of Rho protein signal transduction →	+0.180	+1.037	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,328 associations by consensus.

Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway by IKBKG expression — BREAST

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