IKBKE

Across TCGA patient cohorts, IKBKE mutation is significantly associated with the RNA expression of many other genes, with 2,649 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IKBKE-associated genes across cancer lineages are DOLPP1, NPAP1P3, and RN7SL578P. Each is linked with IKBKE in more than 2 cancer types. Because this analysis shows association rather than direction, both IKBKE-to-partner and partner-to-IKBKE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DOLPP1 grouped by IKBKE-low versus IKBKE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKBKE→partner) and Y-score (partner→IKBKE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DOLPP1 →	+0.594	+2.332	<.001	<.001	3	3
BRCA	NPAP1P3 →	+0.053	+4.109	.009	.001	3	2
CESC	RN7SL578P →	+0.267	+5.103	<.001	.008	3	2
READ	SNX18P23 →	+0.078	+5.653	<.001	.003	3	2
SKCM	RNU6-15P →	+0.253	+2.575	<.001	.004	3	2
CESC	RNU6-1276P →	+0.614	+6.342	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,649 associations by consensus.

DOLPP1 by IKBKE expression — UCEC

Explore this box plot interactively →