IKBKE

Across TCGA pan-cancer cohorts, IKBKE RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of IKBKE’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IKBKE RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IKBKE is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

KIRC, KIRP, and LUAD are the cancer types where IKBKE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IKBKE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.621	<.001	12	view →
KIRP	All	II,III,IV	+1.501	<.001	11	view →
LUAD	Female	III,IV	+1.232	<.001	9	view →
STAD	All	All	+1.348	<.001	8	view →
THCA	All	II,III,IV	+0.587	<.001	8	view →
LIHC	Female	II,III,IV	+1.386	<.001	7	view →
LUSC	Male	All	+1.282	<.001	6	view →
BRCA	All	III,IV	+0.927	<.001	6	view →
CHOL	Female	All	+3.003	<.001	5	view →
KICH	Female	All	−1.016	<.001	5	view →
COAD	All	II,III,IV	+0.379	.004	4	view →
BLCA	All	All	+0.860	.017	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

IKBKE–KIRC

Open the KIRC breakdown →