IKBKE

Across TCGA patient cohorts, IKBKE mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IKBKE-associated genes across cancer lineages are eIF4E, MEK1, and mTOR_pS2448. Each is linked with IKBKE in more than 1 cancer types. Because this analysis shows association rather than direction, both IKBKE-to-partner and partner-to-IKBKE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by IKBKE-low versus IKBKE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKBKE→partner) and Y-score (partner→IKBKE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.160	+2.183	.028	.033	3	2
UCEC	MEK1 →	+0.478	+2.459	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.102	-1.680	.048	.042	3	2
UCEC	Rad50 →	-0.181	-1.440	.031	.024	3	2
BRCA	DUSP4 →	+0.690	+2.814	.015	.037	3	1
UCEC	EGFR_pY1068 →	-0.224	-1.736	.010	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

eIF4E by IKBKE expression — UCEC

Explore this box plot interactively →