IKBKE

Across TCGA cell cohorts, IKBKE mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IKBKE-associated genes across cancer lineages are MYH6, OR12D2, and APCS. Each is linked with IKBKE in more than 1 cancer types. Because this analysis shows association rather than direction, both IKBKE-to-partner and partner-to-IKBKE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH6 grouped by IKBKE-low versus IKBKE-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKBKE→partner) and Y-score (partner→IKBKE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MYH6 →	+0.029	+4.217	<.001	.005	3	1
URINARY_TRACT	OR12D2 →	+0.102	+4.087	.002	.009	3	1
BLOOD_Lymphoma	APCS →	+0.047	+3.523	<.001	.009	3	1
BLOOD_Lymphoma	KNCN →	+0.053	+4.169	<.001	.002	3	1
STOMACH	TMEM114 →	+0.163	+5.285	<.001	.003	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+5.507	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

MYH6 by IKBKE expression — URINARY_TRACT

Explore this box plot interactively →