IKBKB

Across TCGA patient cohorts, IKBKB protein abundance is significantly associated with the RNA expression of many other genes, with 14,225 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IKBKB-associated genes across cancer lineages are BTK, SASH3, and GPAT4. Each is linked with IKBKB in more than 4 cancer types. Because this analysis shows association rather than direction, both IKBKB-to-partner and partner-to-IKBKB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IKBKB versus BTK in GBM, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKBKB→partner) and Y-score (partner→IKBKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BTK →	+0.567	+0.229	.003	<.001	3	5
GBM	SASH3 →	+0.861	+0.292	<.001	<.001	3	5
BRCA	GPAT4 →	+0.789	+0.377	<.001	<.001	3	5
LSCC	FNTA →	+0.552	+0.328	.002	<.001	3	5
LSCC	VDAC3 →	+0.724	+0.361	<.001	<.001	3	5
LSCC	RNF170 →	+0.646	+0.365	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,225 associations by consensus.

IKBKB vs BTK — GBM

Explore this scatter interactively →