IKBKB

Across TCGA pan-cancer cohorts, IKBKB RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IKBKB’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IKBKB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IKBKB is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, THCA, and LIHC are the cancer types where IKBKB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IKBKB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+0.653	<.001	10	view →
THCA	Male	III,IV	−0.642	<.001	9	view →
LIHC	All	II,III,IV	+0.575	<.001	8	view →
CHOL	All	All	+1.810	<.001	5	view →
KICH	Female	All	−0.881	<.001	5	view →
STAD	All	II,III,IV	+0.583	.001	5	view →
KIRP	All	IV	+0.692	.026	2	view →
READ	All	III,IV	+0.469	.039	2	view →
UCEC	All	All	−0.352	.002	2	view →
LUAD	Female	All	+0.398	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

IKBKB–COAD

Open the COAD breakdown →