IKBKB

Across TCGA patient cohorts, IKBKB mutation is significantly associated with the RNA expression of many other genes, with 3,827 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IKBKB-associated genes across cancer lineages are RNA5SP246, SMIM15, and PEX13. Each is linked with IKBKB in more than 2 cancer types. Because this analysis shows association rather than direction, both IKBKB-to-partner and partner-to-IKBKB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP246 grouped by IKBKB-low versus IKBKB-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKBKB→partner) and Y-score (partner→IKBKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP246 →	+0.529	+3.071	.001	.005	3	3
UCEC	SMIM15 →	+0.354	+1.776	.006	.007	3	3
UCEC	PEX13 →	+0.342	+1.227	.002	.006	3	3
SKCM	MNAT1 →	+0.505	+2.497	.005	.009	3	3
UCEC	EXOC5 →	+0.484	+2.058	<.001	<.001	3	3
CESC	MIR920 →	+0.505	+5.539	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,827 associations by consensus.

RNA5SP246 by IKBKB expression — LUAD

Explore this box plot interactively →