IK

Across TCGA patient cohorts, IK mutation is significantly associated with the RNA expression of many other genes, with 1,682 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IK-associated genes across cancer lineages are MTND6P16, MIR4507, and SNORD116-10. Each is linked with IK in more than 1 cancer types. Because this analysis shows association rather than direction, both IK-to-partner and partner-to-IK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND6P16 grouped by IK-low versus IK-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IK→partner) and Y-score (partner→IK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MTND6P16 →	+0.138	+5.824	<.001	.001	3	2
CESC	MIR4507 →	+0.389	+3.705	.003	.008	3	2
SKCM	SNORD116-10 →	+0.283	+5.624	<.001	.002	3	2
BLCA	BRK1P1 →	+0.184	+4.495	<.001	.001	3	2
BLCA	LINC00354 →	+0.130	+4.314	.002	.009	3	2
BLCA	CDY7P →	+0.071	+5.577	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,682 associations by consensus.

MTND6P16 by IK expression — COAD

Explore this box plot interactively →