IHO1

Across TCGA patient cohorts, IHO1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IHO1-associated genes across cancer lineages are Bcl-2, PRAS40_pT246, and ATM. Each is linked with IHO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IHO1-to-partner and partner-to-IHO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bcl-2 grouped by IHO1-low versus IHO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IHO1→partner) and Y-score (partner→IHO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bcl-2 →	-0.268	-2.000	.023	.029	3	2
UCEC	PRAS40_pT246 →	+0.169	+1.261	.003	.029	3	2
UCEC	ATM →	-0.447	-2.906	.003	.001	3	2
UCEC	14-3-3_beta →	-0.100	-2.295	.003	.005	3	1
UCEC	ERK2 →	+0.138	+1.247	.034	.045	3	1
UCEC	FASN →	+0.297	+2.000	.026	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Bcl-2 by IHO1 expression — UCEC

Explore this box plot interactively →