IHO1

Across TCGA pan-cancer cohorts, IHO1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of IHO1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where IHO1 RNA is repressed in tumor relative to normal tissue. In most cancer types IHO1 is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

THCA, BLCA, and LUSC are the cancer types where IHO1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IHO1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.735	<.001	11	view →
BLCA	Male	III,IV	−0.481	<.001	8	view →
LUSC	Male	II,III,IV	−0.286	<.001	8	view →
KICH	All	All	−0.230	<.001	7	view →
KIRC	All	All	+0.214	<.001	7	view →
BRCA	All	III,IV	−0.807	<.001	6	view →
UCEC	All	All	−0.686	<.001	6	view →
LIHC	All	All	+0.074	<.001	5	view →
KIRP	Male	II,III,IV	−0.099	.007	4	view →
HNSC	Female	All	+0.160	.015	3	view →
PRAD	All	All	−0.123	.004	2	view →
CHOL	All	All	+0.133	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

IHO1–THCA

Open the THCA breakdown →