IHO1

Across TCGA cell cohorts, IHO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,264 significant associations in total. BONE shows the largest number of these associations.

The most reproducible IHO1-associated GO terms across cancer lineages are Regulation of homologous chromosome segregation, Protein localization to endosome, and Heterochromatin formation. Each is linked with IHO1 in more than 7 cancer types. Because this analysis shows association rather than direction, both IHO1-to-partner and partner-to-IHO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of homologous chromosome segregation grouped by IHO1-low versus IHO1-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IHO1→partner) and Y-score (partner→IHO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of homologous chromosome segregation →	-0.280	-1.285	<.001	<.001	3	8
BONE	Protein localization to endosome →	+0.150	+0.922	<.001	<.001	3	7
PANCREAS	Heterochromatin formation →	+0.030	+0.021	.005	.003	3	7
BONE	Endosomal transport →	+0.055	+0.943	<.001	<.001	3	6
BONE	Cytosolic transport →	+0.053	+0.806	.001	.003	3	6
BONE	Meiotic DNA double-strand break formation →	-0.958	-1.611	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,264 associations by consensus.

Regulation of homologous chromosome segregation by IHO1 expression — SKIN

Explore this box plot interactively →