IHH

Across TCGA patient cohorts, IHH RNA expression is significantly associated with the protein abundance of many other proteins, with 13,583 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IHH-associated proteins across cancer lineages are ADD3, CHDH, and TPPP3. Each is linked with IHH in more than 5 cancer types. Because this analysis shows association rather than direction, both IHH-to-partner and partner-to-IHH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IHH versus ADD3 in PDAC, with a Pearson correlation of 0.58.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IHH→partner) and Y-score (partner→IHH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ADD3 →	+0.307	+1.194	<.001	<.001	3	6
UCEC	CHDH →	+0.419	+1.466	<.001	<.001	3	5
UCEC	TPPP3 →	+0.941	+1.378	<.001	<.001	3	4
UCEC	TSPAN8 →	+1.827	+2.286	<.001	<.001	3	4
COAD	DDAH2 →	+0.501	+1.466	<.001	<.001	3	4
UCEC	AIFM1 →	+0.387	+1.545	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,583 associations by consensus.

IHH vs ADD3 — PDAC

Explore this scatter interactively →