IHH

Across TCGA pan-cancer cohorts, IHH RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of IHH’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IHH RNA is repressed in tumor relative to normal tissue. In most cancer types IHH is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

LUAD, KICH, and KIRP are the cancer types where IHH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IHH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−2.572	<.001	11	view →
KICH	Male	II,III,IV	−2.183	<.001	9	view →
KIRP	All	III,IV	−1.841	<.001	9	view →
THCA	Male	All	−0.911	<.001	9	view →
LUSC	Female	II,III,IV	−2.878	<.001	8	view →
PAAD	All	All	+3.210	.012	2	view →
UCEC	All	All	+1.776	.029	2	view →
STAD	All	All	+1.402	.021	2	view →
LIHC	Male	All	+1.124	<.001	2	view →
BRCA	All	II,III,IV	+0.032	.028	2	view →
READ	Female	All	+1.034	.003	1	view →
KIRC	Male	All	−0.457	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

IHH–LUAD

Open the LUAD breakdown →