IHH

Across TCGA patient cohorts, IHH mutation is significantly associated with the RNA expression of many other genes, with 2,797 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IHH-associated genes across cancer lineages are RN7SL429P, PRYP2, and RNA5SP489. Each is linked with IHH in more than 2 cancer types. Because this analysis shows association rather than direction, both IHH-to-partner and partner-to-IHH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL429P grouped by IHH-low versus IHH-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IHH→partner) and Y-score (partner→IHH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RN7SL429P →	+0.226	+4.279	<.001	.001	3	3
BRCA	PRYP2 →	+0.104	+7.731	<.001	.009	3	2
BRCA	RNA5SP489 →	+0.388	+8.471	<.001	.005	3	2
UCEC	MIR7702 →	+0.245	+4.360	<.001	.004	3	2
UCEC	RPSAP57 →	+0.046	+2.224	.003	.009	3	2
UCEC	IGHV3-33 →	+2.134	+3.818	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,797 associations by consensus.

RN7SL429P by IHH expression — LUAD

Explore this box plot interactively →