IHH

Across TCGA cell cohorts, IHH RNA expression is significantly associated with the go_rna of many other GO terms, with 2,624 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IHH-associated GO terms across cancer lineages are Ectodermal placode development, Apoptotic DNA fragmentation, and Positive regulation of DNA-templated transcription initiation. Each is linked with IHH in more than 4 cancer types. Because this analysis shows association rather than direction, both IHH-to-partner and partner-to-IHH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ectodermal placode development grouped by IHH-low versus IHH-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IHH→partner) and Y-score (partner→IHH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Ectodermal placode development →	+0.132	+0.051	<.001	.002	3	5
BREAST	Apoptotic DNA fragmentation →	+0.078	+0.078	.001	.003	3	5
SKIN	Positive regulation of DNA-templated transcription initiation →	+0.040	+0.074	.001	.001	3	5
STOMACH	Fatty acid beta-oxidation using acyl-CoA oxidase →	+0.078	+2.034	.003	<.001	3	5
STOMACH	T cell selection →	-0.136	-3.312	<.001	<.001	3	5
STOMACH	Microtubule nucleation by microtubule organizing center →	-0.139	-1.934	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,624 associations by consensus.

Ectodermal placode development by IHH expression — CNS

Explore this box plot interactively →