IHH

Across TCGA cell cohorts, IHH mutation is significantly associated with the drug of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IHH-associated genes across cancer lineages are Nutlin-3a (-), IC-87114, and NSC-207895. Each is linked with IHH in more than 1 cancer types. Because this analysis shows association rather than direction, both IHH-to-partner and partner-to-IHH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nutlin-3a (-) grouped by IHH-low versus IHH-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IHH→partner) and Y-score (partner→IHH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Nutlin-3a (-) →	+1.031	+2.646	.004	.047	3	1
LARGE_INTESTINE	IC-87114 →	+0.244	+2.684	.017	.035	3	1
LARGE_INTESTINE	NSC-207895 →	+0.512	+2.786	.017	.037	3	1
LARGE_INTESTINE	WYE-125132 →	+0.593	+2.652	.019	.045	3	1
LARGE_INTESTINE	AT7867 →	+0.628	+2.652	.008	.045	3	1
LARGE_INTESTINE	Torin 2 →	+0.702	+2.655	.008	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Nutlin-3a (-) by IHH expression — LARGE_INTESTINE

Explore this box plot interactively →