IGSF3

Across TCGA patient cohorts, IGSF3 protein abundance is significantly associated with the RNA expression of many other genes, with 11,920 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGSF3-associated genes across cancer lineages are GAREM1, TRANK1, and PAPSS2. Each is linked with IGSF3 in more than 3 cancer types. Because this analysis shows association rather than direction, both IGSF3-to-partner and partner-to-IGSF3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGSF3 versus GAREM1 in LSCC, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF3→partner) and Y-score (partner→IGSF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GAREM1 →	+0.680	+0.474	<.001	<.001	3	4
UCEC	TRANK1 →	-0.527	-0.325	.003	.008	3	4
HNSC	PAPSS2 →	-0.646	-0.372	<.001	<.001	3	4
HNSC	SERPING1 →	-0.924	-0.504	<.001	<.001	3	4
LSCC	UBN2 →	+0.378	+0.404	<.001	.002	3	4
LSCC	NEDD4L →	+0.686	+0.564	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,920 associations by consensus.

IGSF3 vs GAREM1 — LSCC

Explore this scatter interactively →