IGSF3

Across TCGA pan-cancer cohorts, IGSF3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of IGSF3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IGSF3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGSF3 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where IGSF3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGSF3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.624	<.001	12	view →
KIRC	Male	III,IV	−1.064	<.001	11	view →
BLCA	All	III,IV	+2.143	<.001	10	view →
COAD	Female	II,III,IV	−1.400	<.001	10	view →
LIHC	Female	II,III,IV	+1.970	<.001	9	view →
THCA	Female	III,IV	+1.081	<.001	8	view →
LUSC	Male	All	+1.517	<.001	7	view →
KICH	All	II,III,IV	−1.031	<.001	7	view →
UCEC	All	All	+1.736	<.001	6	view →
BRCA	All	III,IV	+1.196	<.001	6	view →
READ	All	II,III,IV	−1.512	.019	4	view →
CHOL	Female	All	+4.763	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

IGSF3–HNSC

Open the HNSC breakdown →