IGSF3

Across TCGA patient cohorts, IGSF3 mutation is significantly associated with the RNA expression of many other genes, with 3,320 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGSF3-associated genes across cancer lineages are COPS3, SFXN1, and RAD51. Each is linked with IGSF3 in more than 3 cancer types. Because this analysis shows association rather than direction, both IGSF3-to-partner and partner-to-IGSF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COPS3 grouped by IGSF3-low versus IGSF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF3→partner) and Y-score (partner→IGSF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COPS3 →	+0.462	+2.475	<.001	<.001	3	4
UCEC	SFXN1 →	+0.478	+1.669	<.001	<.001	3	4
UCEC	RAD51 →	+0.651	+1.513	<.001	<.001	3	4
COAD	MINDY4 →	-0.341	-3.446	<.001	.005	3	3
LUAD	C18orf54 →	+0.614	+3.608	.001	.001	3	3
UCEC	TIMM21 →	+0.464	+2.050	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,320 associations by consensus.

COPS3 by IGSF3 expression — UCEC

Explore this box plot interactively →