IGSF3

Across TCGA patient cohorts, IGSF3 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGSF3-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and eIF4E. Each is linked with IGSF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGSF3-to-partner and partner-to-IGSF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by IGSF3-low versus IGSF3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF3→partner) and Y-score (partner→IGSF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ASNS →	+0.728	+3.000	.001	.034	3	2
STAD	Caspase-7-cleavedD198 →	+1.103	+3.000	.004	.036	3	2
UCEC	eIF4E →	+0.178	+2.820	.005	.001	3	2
UCEC	Ku80 →	+0.188	+1.543	.008	.002	3	2
UCEC	MSH6 →	-0.305	-1.678	.002	.019	3	2
UCEC	Notch1 →	+0.135	+1.754	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

ASNS by IGSF3 expression — STAD

Explore this box plot interactively →