IGSF3

Across TCGA cell cohorts, IGSF3 mutation is significantly associated with the RNA expression of many other genes, with 510 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IGSF3-associated genes across cancer lineages are ACTL7A, GOLGA8G, and AGTR2. Each is linked with IGSF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGSF3-to-partner and partner-to-IGSF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTL7A grouped by IGSF3-low versus IGSF3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF3→partner) and Y-score (partner→IGSF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ACTL7A →	+0.031	+3.841	<.001	.003	3	3
OESOPHAGUS	GOLGA8G →	+0.089	+2.938	.001	.008	3	2
URINARY_TRACT	AGTR2 →	+0.102	+4.087	.002	.009	3	2
LARGE_INTESTINE	RNF133 →	+0.186	+3.067	.002	.009	3	2
LUNG_NSCLC_LUSC	GAGE12J →	+0.266	+4.643	<.001	.008	3	1
OESOPHAGUS	GPR12 →	+0.015	+3.273	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 510 associations by consensus.

ACTL7A by IGSF3 expression — OVARY

Explore this box plot interactively →