Across TCGA cell cohorts, IGSF23 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,667 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IGSF23-associated GO terms across cancer lineages are Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, Positive regulation of natural killer cell mediated immune response to tumor cell, and Epithelial cell development. Each is linked with IGSF23 in more than 10 cancer types. Because this analysis shows association rather than direction, both IGSF23-to-partner and partner-to-IGSF23 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF23→partner) and Y-score (partner→IGSF23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target →	+0.169	+0.187	.001	.004	2	11
BLOOD_Leukemia	Positive regulation of natural killer cell mediated immune response to tumor cell →	+0.637	+0.046	.001	.008	3	9
OVARY	Epithelial cell development →	+0.078	+0.686	.001	.001	2	8
SOFT_TISSUE	Susceptibility to natural killer cell mediated cytotoxicity →	+0.138	+0.202	.006	.008	2	7
BONE	Negative regulation of cell adhesion →	+0.061	+0.329	.008	.006	3	6
BREAST	Glomerular epithelial cell differentiation →	+0.146	+0.679	.008	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,667 associations by consensus.

Exploration

IGSF23 survival (RNA) · tumor vs normal (RNA) · all IGSF23 data types