IGSF21

Across TCGA patient cohorts, IGSF21 protein abundance is significantly associated with the RNA expression of many other genes, with 7,641 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGSF21-associated genes across cancer lineages are SIDT1, HIF1A, and FBXL16. Each is linked with IGSF21 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGSF21-to-partner and partner-to-IGSF21 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGSF21 versus SIDT1 in LSCC, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF21→partner) and Y-score (partner→IGSF21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SIDT1 →	+1.246	+0.640	<.001	.001	3	3
BRCA	HIF1A →	-1.029	-0.779	<.001	.008	3	2
BRCA	FBXL16 →	+1.441	+0.607	.005	.008	3	2
BRCA	TUT4 →	-0.897	-0.932	.002	<.001	3	2
BRCA	NXPE3 →	+1.134	+0.867	<.001	<.001	3	2
BRCA	DOC2A →	+0.991	+0.633	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,641 associations by consensus.

IGSF21 vs SIDT1 — LSCC

Explore this scatter interactively →