IGSF11

Across TCGA patient cohorts, IGSF11 protein abundance is significantly associated with the RNA expression of many other genes, with 2,435 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGSF11-associated genes across cancer lineages are GNL2, NT5DC2, and GTF2IP4. Each is linked with IGSF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGSF11-to-partner and partner-to-IGSF11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGSF11 versus GNL2 in CCRCC, with a Pearson correlation of -0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF11→partner) and Y-score (partner→IGSF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GNL2 →	-0.321	-0.779	.001	.006	3	2
CCRCC	NT5DC2 →	-0.782	-1.001	.002	.004	3	2
CCRCC	GTF2IP4 →	+1.077	+1.269	.006	.002	3	2
CCRCC	TEN1 →	-0.311	-0.722	<.001	.003	3	2
CCRCC	HOXB6 →	-1.012	-0.858	.002	.005	2	2
CCRCC	MAN1A1 →	+0.776	+0.767	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,435 associations by consensus.

IGSF11 vs GNL2 — CCRCC

Explore this scatter interactively →