IGSF11

Across TCGA patient cohorts, IGSF11 protein abundance is significantly associated with the protein abundance of many other proteins, with 9,063 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGSF11-associated proteins across cancer lineages are SF3B3, SRRT_T544, and TBC1D25_S506. Each is linked with IGSF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGSF11-to-partner and partner-to-IGSF11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGSF11 versus SF3B3 in CCRCC, with a Pearson correlation of -0.81.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF11→partner) and Y-score (partner→IGSF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SF3B3 →	-0.230	-1.100	.002	.002	3	2
GBM	SRRT_T544 →	-0.622	-0.555	<.001	<.001	3	2
CCRCC	TBC1D25_S506 →	-0.513	-0.762	<.001	.001	3	2
CCRCC	THOC1_S560 →	-0.396	-0.812	<.001	<.001	3	2
CCRCC	THOC2 →	-0.346	-0.812	<.001	<.001	3	2
CCRCC	THOC5 →	-0.301	-0.929	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,063 associations by consensus.

IGSF11 vs SF3B3 — CCRCC

Explore this scatter interactively →