IGSF11-AS1

Across TCGA pan-cancer cohorts, IGSF11-AS1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated IGSF11-AS1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher IGSF11-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGSF11-AS1 expression acts as an unfavorable survival marker, although some lineages such as CESC and LUSC show a favorable association.

KICH, CESC, and MESO are the cancer types where IGSF11-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.389	0.917	<.001	141	view →
CESC	DFS	Tertile	All	0.919	0.710	.004	60	view →
MESO	OS	Tertile	III,IV	0.036	0.563	<.001	54	view →
LUSC	OS	Quartile	All	0.512	0.357	.016	27	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	27	view →
KIRC	DFS	Tertile	III,IV	0.242	0.520	.013	24	view →
KIRP	DFS	Tertile	II,III,IV	0.179	0.669	.044	18	view →
LUAD	DFS	Tertile	IV	0.342	0.893	<.001	18	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →
LIHC	OS	Tertile	All	0.546	0.797	.004	9	view →
ACC	DFS	Tertile	All	0.863	0.336	.033	6	view →
SARC	DFS	Tertile	All	0.411	0.539	.040	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

IGSF11-AS1–KICH (DFS)

Open the KICH breakdown →