IGSF11-AS1

Across TCGA pan-cancer cohorts, IGSF11-AS1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IGSF11-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where IGSF11-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGSF11-AS1 is over-expressed in tumor.

LUSC, HNSC, and UCEC are the cancer types where IGSF11-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGSF11-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	+0.041	<.001	6	view →
HNSC	All	II,III,IV	+0.027	.009	4	view →
UCEC	All	IV	+0.130	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

IGSF11-AS1–LUSC

Open the LUSC breakdown →