IGSF1

Across TCGA patient cohorts, IGSF1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,336 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGSF1-associated genes across cancer lineages are RPL18A, DCAF15, and ARHGAP36. Each is linked with IGSF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGSF1-to-partner and partner-to-IGSF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGSF1 versus RPL18A in BRCA, with a Pearson correlation of -0.20.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF1→partner) and Y-score (partner→IGSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL18A →	-0.577	-0.595	.007	.004	3	2
BRCA	DCAF15 →	-0.541	-0.627	.006	.003	3	2
BRCA	ARHGAP36 →	+1.310	+1.065	.002	<.001	3	2
BRCA	CTSO →	+0.573	+0.729	.004	<.001	3	2
GBM	TDP1 →	-0.444	-1.037	<.001	<.001	3	2
HNSC	ECT2 →	-1.170	-0.971	.006	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,336 associations by consensus.

IGSF1 vs RPL18A — BRCA

Explore this scatter interactively →