IGSF1

Across TCGA pan-cancer cohorts, IGSF1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IGSF1 data layer compared with 11 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGSF1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGSF1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

UCEC, BRCA, and SKCM are the cancer types where IGSF1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.552	0.745	<.001	90	view →
BRCA	DFS	Tertile	All	0.970	0.924	<.001	65	view →
SKCM	DFS	Tertile	II,III,IV	0.698	0.410	<.001	53	view →
STAD	DFS	Median	III,IV	0.462	0.685	.002	41	view →
LUAD	DFS	Tertile	All	0.561	0.740	.002	38	view →
LIHC	OS	Quartile	All	0.645	0.838	<.001	32	view →
HNSC	OS	Tertile	II,III,IV	0.174	0.495	.002	20	view →
UVM	DFS	Median	All	0.495	0.946	.001	18	view →
KIRC	DFS	Median	All	0.701	0.555	.004	14	view →
ESCA	DFS	Median	All	0.918	0.495	.012	12	view →
PRAD	DFS	Tertile	All	0.943	0.842	.002	12	view →
KIRP	DFS	Tertile	All	0.864	0.966	.007	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

IGSF1–UCEC (DFS)

Open the UCEC breakdown →