IGSF1

Across TCGA patient cohorts, IGSF1 mutation is significantly associated with the RNA expression of many other genes, with 7,249 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGSF1-associated genes across cancer lineages are SPC24, CENPS, and NDC80. Each is linked with IGSF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both IGSF1-to-partner and partner-to-IGSF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPC24 grouped by IGSF1-low versus IGSF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF1→partner) and Y-score (partner→IGSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPC24 →	+0.421	+1.285	.004	.001	3	5
SKCM	CENPS →	+0.257	+1.407	.001	.001	3	5
COAD	NDC80 →	+0.577	+2.713	.001	.002	3	5
UCEC	PHF5A →	+0.534	+3.029	<.001	<.001	3	4
UCEC	POLE2 →	+0.474	+1.436	<.001	<.001	3	4
UCEC	CDKN3 →	+0.721	+2.010	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,249 associations by consensus.

SPC24 by IGSF1 expression — UCEC

Explore this box plot interactively →