IGSF1

Across TCGA patient cohorts, IGSF1 mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGSF1-associated genes across cancer lineages are RAD51, TFRC, and Cyclin-B1. Each is linked with IGSF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both IGSF1-to-partner and partner-to-IGSF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by IGSF1-low versus IGSF1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF1→partner) and Y-score (partner→IGSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RAD51 →	+0.169	+2.593	.010	.006	3	5
STAD	TFRC →	+0.710	+2.321	.011	.034	3	4
UCEC	Cyclin-B1 →	+0.563	+1.502	<.001	<.001	3	4
COAD	Caspase-7-cleavedD198 →	+1.268	+3.016	<.001	.018	3	4
COAD	GAPDH →	+0.499	+2.593	.018	.006	3	3
COAD	Smad4 →	+0.158	+3.321	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

RAD51 by IGSF1 expression — COAD

Explore this box plot interactively →