IGSF1

Across TCGA cell cohorts, IGSF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,527 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible IGSF1-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Adenylate cyclase-activating G protein-coupled receptor signaling pathway, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with IGSF1 in more than 7 cancer types. Because this analysis shows association rather than direction, both IGSF1-to-partner and partner-to-IGSF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by IGSF1-low versus IGSF1-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF1→partner) and Y-score (partner→IGSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Negative regulation of myoblast fusion →	+0.120	+0.724	<.001	.001	3	8
SOFT_TISSUE	Adenylate cyclase-activating G protein-coupled receptor signaling pathway →	-0.069	-0.804	<.001	.002	3	7
BLOOD_Lymphoma	Negative regulation of syncytium formation by plasma membrane fusion →	+0.117	+0.724	<.001	.001	3	7
SKIN	RNA localization →	+0.073	+0.672	<.001	.009	3	7
SOFT_TISSUE	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway →	-0.068	-0.845	<.001	.001	2	7
STOMACH	Cytoplasmic translation →	+0.090	+0.990	<.001	.005	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,527 associations by consensus.

Negative regulation of myoblast fusion by IGSF1 expression — BLOOD_Lymphoma

Explore this box plot interactively →