IGSF1

Across TCGA cell cohorts, IGSF1 mutation is significantly associated with the RNA expression of many other genes, with 473 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IGSF1-associated genes across cancer lineages are KRTAP2-4, ZSWIM7, and RXFP2. Each is linked with IGSF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGSF1-to-partner and partner-to-IGSF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP2-4 grouped by IGSF1-low versus IGSF1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF1→partner) and Y-score (partner→IGSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRTAP2-4 →	+0.122	+4.930	<.001	.008	3	2
SKIN	ZSWIM7 →	+0.508	+2.043	.003	.008	3	2
LUNG_NSCLC_LUAD	RXFP2 →	+0.033	+2.959	<.001	.004	3	2
LUNG_NSCLC_LUAD	CT45A2 →	+1.453	+3.243	<.001	.001	3	2
LUNG_NSCLC_LUAD	GAGE13 →	+1.495	+2.781	.001	.008	3	2
LARGE_INTESTINE	TTC33 →	+0.666	+3.743	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 473 associations by consensus.

KRTAP2-4 by IGSF1 expression — SOFT_TISSUE

Explore this box plot interactively →