IGLVV-66

Across TCGA pan-cancer cohorts, IGLVV-66 RNA is linked to patient survival in 7 of 34 cancer types, making it the most broadly survival-associated IGLVV-66 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher IGLVV-66 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGLVV-66 expression acts as an unfavorable survival marker, although some lineages such as PAAD and LGG show a favorable association.

LUSC, ESCA, and OV are the cancer types where IGLVV-66 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Tertile	III,IV	0.203	0.575	.014	63	view →
ESCA	DFS	Tertile	All	0.148	0.673	.040	18	view →
OV	OS	Tertile	II,III,IV	0.528	0.845	.017	18	view →
PAAD	OS	Tertile	II,III,IV	0.779	0.348	.018	12	view →
LGG	DFS	Tertile	All	0.973	0.823	.024	12	view →
SKCM	OS	Tertile	III,IV	0.219	0.702	.002	9	view →
UCEC	OS	Tertile	All	0.889	0.929	.044	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

IGLVV-66–LUSC (OS)

Open the LUSC breakdown →