IGLVIV-66-1

Across TCGA pan-cancer cohorts, IGLVIV-66-1 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated IGLVIV-66-1 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher IGLVIV-66-1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGLVIV-66-1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

LUSC, OV, and BLCA are the cancer types where IGLVIV-66-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Tertile	III,IV	0.341	0.601	.015	45	view →
OV	OS	Tertile	IV	0.022	0.760	<.001	36	view →
BLCA	DFS	Tertile	IV	0.109	0.481	<.001	36	view →
SKCM	OS	Tertile	All	1.000	0.848	.010	27	view →
GBM	OS	Tertile	All	0.103	0.415	.003	18	view →
DLBC	OS	Tertile	All	0.053	0.936	<.001	18	view →
COAD	OS	Tertile	III,IV	0.191	0.701	.038	18	view →
PRAD	OS	Tertile	All	0.906	0.990	<.001	18	view →
THCA	DFS	Tertile	All	0.721	0.921	.011	9	view →
READ	OS	Tertile	All	0.535	0.909	.004	9	view →
THYM	OS	Tertile	All	0.808	0.971	.035	6	view →
UCEC	OS	Tertile	III,IV	0.668	0.837	.048	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

IGLVIV-66-1–LUSC (OS)

Open the LUSC breakdown →