IGLVIV-64

Across TCGA pan-cancer cohorts, IGLVIV-64 RNA is linked to patient survival in 6 of 34 cancer types, making it the most broadly survival-associated IGLVIV-64 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher IGLVIV-64 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGLVIV-64 expression acts as an unfavorable survival marker, although some lineages such as ESCA show a favorable association.

BRCA, HNSC, and CESC are the cancer types where IGLVIV-64 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Tertile	IV	0.175	0.730	.005	36	view →
HNSC	DFS	Tertile	III,IV	0.206	0.505	.026	36	view →
CESC	OS	Tertile	IV	0.108	0.619	<.001	36	view →
DLBC	OS	Tertile	II,III,IV	0.118	0.802	.025	18	view →
KIRC	DFS	Tertile	IV	0.219	0.620	.001	18	view →
ESCA	OS	Tertile	All	0.845	0.440	.047	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

IGLVIV-64–BRCA (DFS)

Open the BRCA breakdown →