IGLVIV-59

Across TCGA pan-cancer cohorts, IGLVIV-59 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated IGLVIV-59 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher IGLVIV-59 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGLVIV-59 expression acts as an unfavorable survival marker, although some lineages such as PAAD and SKCM show a favorable association.

COAD, PAAD, and LUSC are the cancer types where IGLVIV-59 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	IV	0.101	0.658	<.001	78	view →
PAAD	DFS	Tertile	All	0.683	0.227	<.001	39	view →
LUSC	OS	Tertile	III,IV	0.079	0.803	<.001	36	view →
STAD	DFS	Tertile	II,III,IV	0.382	0.559	.010	27	view →
TGCT	DFS	Tertile	II,III,IV	0.526	0.951	.011	18	view →
CESC	DFS	Tertile	II,III,IV	0.193	0.705	.045	18	view →
PCPG	DFS	Tertile	All	0.535	0.936	<.001	18	view →
SKCM	DFS	Tertile	II,III,IV	0.825	0.269	.014	12	view →
ESCA	OS	Tertile	III,IV	0.846	0.367	.038	12	view →
MESO	DFS	Tertile	III,IV	0.933	0.351	.048	9	view →
KIRP	DFS	Tertile	All	1.000	0.838	.035	8	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

IGLVIV-59–COAD (OS)

Open the COAD breakdown →