IGLVIV-53

Across TCGA pan-cancer cohorts, IGLVIV-53 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated IGLVIV-53 data layer.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher IGLVIV-53 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGLVIV-53 expression acts as an unfavorable survival marker.

READ, LIHC, and KICH are the cancer types where IGLVIV-53 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Tertile	III,IV	0.330	0.900	<.001	72	view →
LIHC	DFS	Tertile	III,IV	0.076	0.360	.001	72	view →
KICH	DFS	Tertile	All	0.102	0.848	.004	39	view →
ESCA	OS	Tertile	All	0.198	0.872	.003	36	view →
CESC	DFS	Tertile	All	0.184	0.823	<.001	36	view →
LUAD	OS	Tertile	II,III,IV	0.150	0.677	.008	18	view →
PCPG	DFS	Tertile	All	0.161	0.819	.004	18	view →
BRCA	OS	Tertile	All	0.822	0.925	.036	12	view →
LUSC	OS	Tertile	All	0.358	0.727	.028	9	view →
STAD	DFS	Tertile	All	0.197	0.414	.041	6	view →
UCEC	OS	Tertile	All	0.863	0.929	.028	6	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

IGLVIV-53–READ (OS)

Open the READ breakdown →