IGLVI-70

Across TCGA pan-cancer cohorts, IGLVI-70 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated IGLVI-70 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLVI-70 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGLVI-70 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and ACC are the cancer types where IGLVI-70 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.791	0.633	<.001	114	view →
SKCM	OS	Tertile	All	0.488	0.296	.002	47	view →
ACC	DFS	Tertile	III,IV	0.039	0.381	.008	30	view →
BRCA	OS	Quartile	All	0.689	0.558	.012	29	view →
LUAD	DFS	Quartile	II,III,IV	0.882	0.647	.010	28	view →
GBM	OS	Tertile	All	0.259	0.434	.001	27	view →
CHOL	DFS	Median	All	0.696	0.248	.016	24	view →
CESC	OS	Median	III,IV	0.765	0.503	.013	22	view →
READ	DFS	Tertile	IV	0.908	0.330	.001	21	view →
OV	DFS	Median	All	0.204	0.125	.003	20	view →
PAAD	OS	Quartile	II,III,IV	0.736	0.501	.006	13	view →
COAD	DFS	Median	III,IV	0.629	0.494	.026	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

IGLVI-70–HNSC (OS)

Open the HNSC breakdown →