IGLVI-56

Across TCGA pan-cancer cohorts, IGLVI-56 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated IGLVI-56 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher IGLVI-56 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGLVI-56 expression acts as an unfavorable survival marker, although some lineages such as SKCM and COAD show a favorable association.

SKCM, LIHC, and THCA are the cancer types where IGLVI-56 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Tertile	II,III,IV	0.865	0.527	.001	63	view →
LIHC	OS	Tertile	II,III,IV	0.059	0.772	<.001	36	view →
THCA	OS	Tertile	III,IV	0.682	0.868	.012	27	view →
COAD	OS	Tertile	All	0.830	0.527	.023	21	view →
KIRP	OS	Tertile	All	0.749	0.899	.011	21	view →
HNSC	DFS	Tertile	IV	0.469	0.290	.018	21	view →
OV	OS	Tertile	III,IV	0.451	0.297	.019	18	view →
TGCT	DFS	Tertile	II,III,IV	0.526	0.951	.011	18	view →
LUAD	DFS	Tertile	All	0.752	0.626	.003	18	view →
PCPG	DFS	Tertile	All	0.747	0.927	.011	15	view →
ESCA	DFS	Tertile	II,III,IV	0.568	0.302	.020	9	view →
DLBC	OS	Median	All	1.000	0.788	.029	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

IGLVI-56–SKCM (DFS)

Open the SKCM breakdown →