IGLVI-56

Across TCGA pan-cancer cohorts, IGLVI-56 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IGLVI-56’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where IGLVI-56 RNA is repressed in tumor relative to normal tissue. In most cancer types IGLVI-56 is over-expressed in tumor, although a few such as KIRP and COAD show the opposite, repressed pattern.

KIRP, KICH, and COAD are the cancer types where IGLVI-56 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGLVI-56 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	−0.190	<.001	8	view →
KICH	All	All	+1.179	<.001	6	view →
COAD	All	All	−0.220	.013	5	view →
READ	All	All	−0.271	.011	4	view →
KIRC	All	All	−0.114	<.001	4	view →
LUAD	All	All	+0.139	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

IGLVI-56–KIRP

Open the KIRP breakdown →