IGLVI-42

Across TCGA pan-cancer cohorts, IGLVI-42 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated IGLVI-42 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher IGLVI-42 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGLVI-42 expression acts as an unfavorable survival marker.

THCA, PCPG, and HNSC are the cancer types where IGLVI-42 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	All	0.240	0.931	<.001	54	view →
PCPG	DFS	Tertile	All	0.074	0.867	<.001	36	view →
HNSC	DFS	Tertile	III,IV	0.179	0.615	.005	36	view →
LUAD	DFS	Tertile	IV	0.342	0.893	<.001	36	view →
DLBC	OS	Tertile	III,IV	0.272	1.000	.017	28	view →
LUSC	DFS	Tertile	II,III,IV	0.139	0.663	.027	27	view →
STAD	DFS	Tertile	All	0.502	0.668	.030	9	view →
UVM	OS	Tertile	All	0.315	0.711	.049	9	view →
SKCM	DFS	Tertile	All	0.350	0.615	.035	6	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

IGLVI-42–THCA (OS)

Open the THCA breakdown →