IGLVI-20

Across TCGA pan-cancer cohorts, IGLVI-20 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated IGLVI-20 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLVI-20 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGLVI-20 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, UVM, and DLBC are the cancer types where IGLVI-20 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.871	0.696	.002	108	view →
UVM	OS	Tertile	All	0.104	0.858	<.001	99	view →
DLBC	DFS	Tertile	II,III,IV	0.065	0.829	<.001	63	view →
OV	OS	Tertile	IV	0.244	0.651	.002	36	view →
SKCM	DFS	Tertile	All	0.767	0.598	.004	33	view →
LUSC	OS	Tertile	II,III,IV	0.528	0.676	.004	26	view →
BRCA	DFS	Tertile	II,III,IV	0.979	0.931	.016	24	view →
STAD	OS	Tertile	IV	0.805	0.283	.031	21	view →
COAD	DFS	Tertile	All	0.685	0.474	.010	18	view →
ESCA	DFS	Tertile	II,III,IV	0.571	0.283	.023	15	view →
KIRP	DFS	Tertile	All	0.769	0.865	.043	12	view →
PAAD	DFS	Tertile	II,III,IV	0.578	0.374	.021	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

IGLVI-20–HNSC (OS)

Open the HNSC breakdown →